Human recombinant laminin-211 |
| Human recombinant Laminin-211 supports the growth, survival and differentiation of a wide range of tissue-specific cell types, including motor neurons, cardiac and skeletal muscle cells |
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| Laminin-211 (laminin-2) is produced by myocytes in heart, and skeletal and smooth muscle tissues (Allamand et al., 1997; Helbling-Leclerc et al., 1995). In addition, constitutive expression of Laminin-211 is found in mouse and human thymic tissue vital for lymphoepithelial interactions (Ocampo et al., 2008). |
Neural stem cells |
Myelin sheaths |
Muscle cells |
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Laminin-211 is a major laminin isoform synthezied by Schwann cells in the developing peripheral nervous system, important for axonal elongation/neurite extension and myelinization (Patton, 2000; Patton et al., 2001; Wallquist et al., 2005).
Laminins containing the α2-chain (such as Laminin-211) are expressed in the ventricular zone ECM in the developing mouse central nervous system. Since laminins are known to contribute to the stem cell niche in the brain, this suggests that Laminin-211 could play an important functional role in the regulation of neural stem cells (Haubst et al., 2006; Kazanis et al., 2010; Lathia et al., 2007; Mercier et al., 2002). |
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