RPE's in Preclinical Model
Plaza Reyes A., Petrus-Reurer S., Antonsson L., Stenfelt S., Bartuma H., Panula S., Mader T., Douagi I., André H., Hovatta O., Lanner F., Kvanta A.
Stem Cell Reports, 2016
Here the authors describe production of hESC-RPE cells in a xeno-free and defined manner and present evidence of functional integration of clinically compliant hESC-RPE in a large-eyed disease model. Human recombinant laminin-521 effectively supports differentiation of clinically compliant hESC-RPE that are effeiciently used in a minimally invasive surgical procedure for high-yield functional long-term hESC-RPE integration with photoreceptor preservation. These findings have important implications for ongoing and future clinical studies for the development of a safe and efficient cell replacement therapy for geographic atrophy.