WHATEVER YOUR RESEARCH AIM IS, YOU NEED A CULTURE SUBSTRATE THAT GUARANTEES THE HIGHEST CELL QUALITY AND YIELD.

We offer an expansive portfolio of human recombinant laminin cell culture substrates for a variety of applications, including reliable expansion of pluripotent cell and differentiation and maintenance of specialized cell types.

All our matrices are chemically defined and animal component-free and allow you to imitate the natural cell-matrix interactions in vitro

The authentic cell culture environment provides more consistent and reliable cellular responses and improves cell functionality. 

 

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Click on the icons below to read more about how Biolaminin substrates can be used for specific cell applications        

stem cell culture and on biorelevant cell culture substrates

hPSC DERIVATION AND EXPANSION 
& iPSC REPROGRAMMING AND EXPANSION

CLONAL STEM CELL CULTURE

NEURONSGLIA
& NEURAL STEM CELLS

SKELETAL MUSCLE CELLS

HEPATOCYTES & HEPATOBLAST CELLS

PANCREATIC ISLETS & BETA CELLS

HEMATOPOIETIC STEM CELLS
& BLOOD CELLS

MESENCHYMAL STEM CELLS

KIDNEY CELLS

HAIR FOLLICLE CELLS
& SKIN CELLS

RETINAL CELLS, CORNEAL CELLS
& PHOTORECEPTORS

MAMMARY GLAND CELLS

LUNG CELLS

CARDIOMYOCYTES

SPLEEN CELLS

ENDOTHELIAL CELLS

THYMOCYTES
& IMMUNE CELLS

ADIPOSE CELLS

INTESTINAL CELLS

GERM CELLS

BONE 
& CARTILAGE CELLS 

CANCER CELLS 

ANIMAL STEM CELLS 

                                                                                                           DOWNLOAD THE LAMININ CELL CULTURE APPLICATIONS POSTER  

Biologically relevant cell culture matrix

Biologically relevant

A biologically relevant matrix that mimics the authentic ECM-cell interaction for improved cell performance.

Defined and animal component-free

Defined and animal-free

The products are defined and animal component-free. All materials used in the production of Biolaminin 521 CTG have full traceability.

Minimized variation

Minimized variation

No lot-to-lot variation and uniformed pluripotency gene expression patterns between different cell lines gives more standardized experiments.

Effective specialization

Effective specialization

More efficient differentiation, enhanced cell maturation, polarization and organization of specialized cell types, such as hepatocytes, cardiomyocytes and neurons.

High quality and yield

High quality and yield

Fast proliferation rate with maintained genetic integrity and stemness, facilitates the use of low passage cell lines for the production of clinically relevant cell numbers of differentiated cell types.

 

Full documentation

Full documentation

Full traceability documentation, such as Certificate of Origin and Certificate of Analysis are available for the cell therapy grade Biolaminin 521.

Laminin molequleWhile many protocols successfully recapitulate the temporal developmental processes via well designed medium formulations, the majority of protocols ignore the role of basement membrane proteins. Adhesion is not only about making cells stick, but also about the interaction between the culture substrate and cells which can influence cell behavior. The type of cell culture substrate used will have a great impact on your research and will save you both time and cost. 

Laminins are large multidomain, glycoproteins of the extracellular matrix. They are a major component of the basal lamina of the basement membrane, a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. Laminins are heterotrimeric proteins that contain an α-chain, a β-chain, and a γ-chain, found in five, four, and three genetic variants, respectively. There are to date at least 16 distinct isoforms identified in mammals, named based on their chain composition. The assembled laminin molecule forms a cross-like structure that can bind to other extracellular matrix molecules and to cellular receptors, which helps anchor organized tissue cells to the membrane.

BioLamina's Biolaminin substrates are the only original full length, recombinant laminins on the market. There are many binding sites on the full-length laminin molecule which can interact with cell membrane receptors, triggering vital intracellular signaling pathways and regulate cellular responses, such as cell anchorage, survival, proliferation, migration, organization and specialization.

 

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"Biolaminin 521 have simplified the day-to-day expansion of our human pluripotent stem cells and significantly reduced the operator time. Our new costs are only a fraction of what they used to be when we relied MEFs."

 

 

 
"WOW!
I wasted so much time on other stuff."

 

"We have struggled to establish a GMP manufacturing process for a DA neuron therapy for Parkinson's Disease. The recombinant laminins from Biolamina really made a world of difference! We have a greater efficiency than ever before and we now have a high yield, high quality GMP differentiation protocol ready to use."

 

 

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Events & Meetings

Our next meetings are:

Cell & Gene Therapy World 2019
22-25 January, Miami, USA


Overview Events & Meetings 2019 

 

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Keep up to date with news from BioLamina:

Social media:
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Newsletter:
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Press Room:
BioLamina Press Room

Stem cell culture

Pluripotent stem cell culture is easy on human recombinant Biolaminin 521 substrates. The Biolaminin 521 LN (LN521) stem cell matrix is a feeder-free, chemically defined and animal component-free cell culture system that support high cell survival and fast proliferation of hESC and iPSC. 

The LN521 matrix is biologically relevant and allows low density seeding of single cells without need of ROCKi. The cells grow as a homogenous monolayers and remain pluripotent without spontaneous differentiation.

Watch more cell culture videos and webinars here!

  • x
  • Expansion of human PSC

  • Mesenchymal stem cells

  • Clonal cell culture applications

  • Eye cells

  • Cardiac cells

  • Neural cells

  • Skeletal muscle cells

  • Kidney cells

  • Hepatic cells

  • Cancer cells

  • Lung cells

  • Animal stem cells

  • Endothelial cells

  • Pancreatic cells

  • Intestinal cells

  • Normal and cancerous mammary cells

  • Epithelial cells

Biolaminin 521 CTG

Biolaminin 521 CTG cell therapy grade cell culture matrix makes pluripotent stem cell culture easy. A defined, animal component-free and biologically relevant cell culture system for better cell models.

  • x
  • Expansion of human PSC

  • Clonal cell culture applications

  • Eye cells

  • Cardiac cells

  • Neural cells

  • Skeletal muscle cells

  • Kidney cells

  • Hepatic cells

  • Cancer cells

  • Lung cells

  • Animal stem cells

  • Mesenchymal stem cells

  • Endothelial cells

  • Pancreatic cells

  • Intestinal cells

  • Normal and cancerous mammary cells

  • Epithelial cells

Biolaminin 521 MX

Biolaminin 521 MX research grade cell culture matrix makes pluripotent stem cell culture easy. A defined, animal component-free and biologically relevant cell culture system for better cell models.

  • x
  • Expansion of human PSC

  • Mesenchymal stem cells

  • Clonal cell culture applications

  • Eye cells

  • Cardiac cells

  • Neural cells

  • Skeletal muscle cells

  • Kidney cells

  • Hepatic cells

  • Cancer cells

  • Lung cells

  • Animal stem cells

  • Endothelial cells

  • Pancreatic cells

  • Intestinal cells

  • Normal and cancerous mammary cells

  • Epithelial cells

Biolaminin 521 LN

Biolaminin 521 LN research grade cell culture matrix makes pluripotent stem cell culture easy. A defined, animal component-free and biologically relevant cell culture system for better cell models.